This book provides a comprehensive and up-to-date account of the physical/technological, biological, and clinical aspects of SBRT. It will serve as a detailed resource for this rapidly developing treatment modality. The study by Nicholas James and colleagues (March 19, p 1163)1 shows that the addition of docetaxel to androgen deprivation therapy improved survival in patients with hormone-sensitive metastatic, high-risk, node-positive, or recurrent 234 www.thelancet.com Vol 388 July 16, 2016 New approaches are urgently needed. A meta-analysis with other docetaxel and zoledronic acid-containing trials has been conducted and is reported separately. Addition of docetaxel or bisphosphonates to standard of care in men with localised or metastatic, hormone-sensitive prostate cancer: a systematic review and meta-analyses of aggregate data. Found insideHowever, the meta-analyses compared the overlapped treatment arms (ADT+docetaxel vs ADT+abiraterone acetate) of STAMPEDE trial to give the evidence of no ... As our cohort may be less likely to die from intercurrent illness, particularly cardiovascular, PCa was the leading cause of death. Adding abiraterone or docetaxel to long-term hormone therapy for prostate cancer: directly randomised data from the STAMPEDE multi-arm, multi-stage platform protocol Ann Oncol . I STARTED STAMPEDE TRIAL ARM E IN MAY 2010 AND SINCE THEN HAVE BEEN RELEASED FROM THE TRIAL, BECAUSE RESULTS FOR TRIAL ARM E HAVE BEEN PUBLICISED. Addition of docetaxel, zoledronic acid, or both to first-line long-term hormone therapy in prostate cancer (STAMPEDE): survival results from an adaptive, multiarm, multistage, platform randomised controlled trial. The STAMPEDE trial offers a direct, randomised, comparative analysis of two new standards for patients with hormone naive prostate cancer. 4,5,21 The STAMPEDE trial … In the future, other trials may also look at the three therapies—abiraterone, docetaxel… STAMPEDE aims to provide evidence as to what is the best way of treating men with newly diagnosed advanced prostate cancer. Found inside – Page 1104The multiarm STAMPEDE trial also had a comparison of adding docetaxel to standard ADT and confirmed the benefit to men with castrate-naïve metastatic ... Abiraterone has been tested in STAMPEDE, and the researchers plan to report cost-effectiveness and quality-of-life measures for this treatment later in 2018. As shown in the STAMPEDE and CHAARTED trials, the docetaxel/ADT regimen increases overall survival in this setting. 24,25 The increase in survival was maintained regardless of disease volume in the STAMPEDE trial and primarily in high-volume patients in the CHAARTED trial. 24 As per the STAMPEDE trial, upfront docetaxel improved the OS irrespective … It works by disrupting the microtubular network that is essential for mitotic and interphase cellular functions, causing inhibition of cell division and cell death (Docetaxel for the treatment of hormone-refractory metastatic prostate … Despite the numerous regulatory approvals for prostate cancer, metastatic prostate cancer remains a huge burden for men worldwide. Found insideThese novel clinical trial designs can dramatically increase the cost-effectiveness of drug development, leading to life-altering medicines for people suffering from serious illnesses, possibly at lower cost. The analysis presented today uses prospectively collected data from the STAMPEDE trial to directly compare patients randomised to the docetaxel and … The results of arm C in the large, multiarm, multistage, platform STAMPEDE trial (ClinicalTrials.gov identifier NCT00268476) were presented around the same time, reporting the clinical outcomes of the addition of docetaxel to ADT versus ADT alone. This was done at the investigator’s discretion until 2017, at which point, following the publication of the LATITUDE (NCT01715285) and STAMPEDE (NCT00268476) trials, docetaxel … Found insideThe book will be of value for all practicing urooncologists as well as other oncology fellows and residents interested in urooncology. The trial is currently using enzalutamide and abiraterone in combination with hormone therapy or, for newly diagnosed metastatic patients only, radiotherapy in combination with hormone therapy. Recruitment started in 2005 and ends in 2022 and in January 2020, over 10,000 participants have joined the trial. Choosing Between Docetaxel or Abiraterone With ADT in Hormone-Sensitive Prostate Cancer. 21st June 201 . The STAMPEDE trial is a multi-arm, multi-stage trial designed so that different interventions can be tested in a sequential fashion; the trial was one of … Found inside – Page 1251The toxicity profile of docetaxel is well understood and managed after a decade of ... in the STAMPEDE trial (NCT00268476) and the ECOG-E3805 CHAARTED trial ... The object of the present analysis was to evaluate the cost-effectiveness of these treatment options in the treatment of advanced hormone-naive prostate cancer in China. May 17, 2018. Results from the STAMPEDE trial, the largest randomized trial of treatment for prostate cancer, show that adding docetaxel, but not zolendronic acid, to long-term hormone therapy in treatment-naïve men with high-risk locally advanced or metastatic prostate cancer significantly improves survival. Abstract. In findings from the STAMPEDE trial, a trial that has enrolled more than 9000 men with M0 and M1 prostate cancer since 2005, the addition of docetaxel (Taxotere) to frontline long-term hormone therapy improved quality of life and reduced the need for subsequent therapy in … Please note, some parts of the STAMPEDE trial have results. recently published data from the Systemic Therapy in Advanced or Metastatic Prostate Cancer: Evaluation of Drug Efficacy: a multi-stage multi-arm randomised control trial (STAMPEDE). Ariela Katz. The trial team have published some results for the STAMPEDE trial. Immunotherapy is a rapidly evolving field that mandates frequent revision of the book as new insights to fight cancer emerge. Prior to the STAMPEDE trial the standard of care for prostate cancer had not changed for many decades. The treatment effect of the addition of docetaxel to ADT plus RT on OS also differed in men with PSA levels <4 ng/mL versus men with PSAs of … Systemic Therapy in Advancing or Metastatic Prostate Cancer: Evaluation of Drug Efficacy (STAMPEDE) is a clinical trial investigating treatments for high risk or terminal prostate cancer. Survival with newly diagnosed metastatic prostate cancer in the “docetaxel era”: data from 917 patients in the control arm of the STAMPEDE trial … Celecoxib, zoledronic acid, docetaxel and abiraterone alone have previously been tested. Found inside – Page 50One arm of the large STAMPEDE trial randomly assigning men to either ADT plus docetaxel chemotherapy or ADT alone and recruited 1184 men with metastatic or ... It recruits men with high-risk, locally advanced, metastatic or recurrent prostate cancer who are starting first-line long-term hormone therapy. Cancer Research UK supports this trial. How Randomized Trials of STAMPEDE Have Influenced Treatment Decisions in the United Kingdom. User Posted 08 Feb 2020 at 00:39. Found insideAdditionally, only one patient died of treatmentrelated causes in the docetaxel arm, and none in the ADT alone arm. The STAMPEDE trial, reported by James et ... Docetaxel (DOC) and abiraterone (ABI) both improve overall survival (OS) in men with locally advanced or metastatic hormone-sensitive prostate cancer (HSPC) but no head to head trials compare the 2 agents. Found inside – Page iiImportantly, there has been constant evolution of the best way to treat these patients. This text will provide a single, comprehensive reference source that incorporates all the latest information regarding prostate cancer. To address this challenge to the treatment of high-risk prostate cancer, researchers from MRC Clinical Trials Unit at UCL brought an idea to test a variety of current treatments in men with high-risk prostate cancer to the NCRI Prostate Group . Introduction: Abiraterone acetate (plus prednisone) and enzalutamide are both approved therapies for men with metastatic castration-resistant prostate cancer (mCRPC), with similar improvement in progression-free survival and overall ... Herein, we use data from the STAMPEDE trial’s M1 RT comparison 1 to explore the association of bone metastatic burden and the influence of isolated or concomitant nodal or ... with up-front docetaxel permitted in patients randomized after December 17, 2015. In summary, the main findings are: adding docetaxel to hormone therapy improves the … Found inside – Page 45Finally, the STAMPEDE trial represents the third Phase III randomized controlled trial investigating the addition of docetaxel to ADT for the treatment of ... This film explores the results of the STAMPEDE trial. STAMPEDE looked at whether adding docetaxel or zoledronic acid, or a combination of both, to standard treatment… The STAMPEDE trial evaluated the role of docetaxel in newly diagnosed metastatic prostate cancer. Found insideThis pocket book explains the significant and well-documented impact that PET/CT can have on the management of prostate cancer through the provision of high-quality evidence regarding function and structure. Introduction. The same meta-analysis examined 11 trials of docetaxel for men with M0 disease and included GETUG-12 , RTOG-0521 and STAMPEDE-M0 trials . Initially, SOC was ADT alone, but from October 2015 onward, the use of docetaxel was permitted. Several other trials in addition to STAMPEDE have assessed both drugs in the newly diagnosed setting, most notably GETUG-15 and CHAARTED, which assessed docetaxel in the metastatic setting (about 60% of the population used in our trial). Survival with Newly Diagnosed Metastatic Prostate Cancer in the "Docetaxel Era": Data from 917 Patients in the Control Arm of the STAMPEDE Trial (MRC PR08, CRUK/06/019) Results from this control arm cohort found survival is relatively short and highly influenced by patient age, fitness, and where prostate cancer has spread in the body. Management of Advanced Prostate Cancer will be a valuable resource for practitioners at all levels of expertise. Targeted Therapies in Oncology, May 2018, Volume 7, Issue 5. The median overall survival was not reached for both drugs abi or docetaxel at 48 months. Found inside – Page iThis work benefits not only Asian urologists but also their Western counterparts and all physicians and medical personnel who are involved in the treatment of PCa. Of all studies included in this NMA, the STANPEDE trial is the only RCT that compared docetaxel and abiraterone for their QOL impact [48]. The STAMPEDE trial is a randomized controlled trial which employs a multi-arm multi-stage platform design to test whether the … We modelled health outcomes and costs in the UK NHS using data collected within the STAMPEDE trial, which enrolled men with high-risk, locally advanced metastatic or recurrent PC starting first-line hormone therapy. Version 1.2 (May 2015) Page 6 of 7 ... Docetaxel 75mg/m2 in 250ml sodium chloride 0.9% intravenous infusion over 60 minutes Administration Instructions Ensure the patient has taken the dexamethasone pre-medication prior to treatment. Take-home messages. Natural Autoantibodies provides an in-depth analysis of all aspects of natural antibodies. The book examines the advantages and pitfalls of every type of technique that is widely used for detecting autoantibodies. Data from the control arm of the STAMPEDE trial show that survival remains poor, particularly for younger men with bony metastatic prostate cancer. Thus meta-analysis is expected to settle the controversy. ASCO 2017 - Prof Nicholas James Addition of docetaxel to first-line long-term hormone therapy in prostate cancer (STAMPEDE): long-term survival, quality-adjusted survival and cost-effectiveness analysis. ... (STAMPEDE, NCT00268476) attempt to compare the efficacy ... in a 1:1 ratio, patients who had previously received docetaxel and an … This trial is comparing hormone therapy alone with a combination of hormone therapy and one or more other treatments for prostate cancer. We have a separate summary of the STAMPEDE trial results. Taken together, these volumes form one comprehensive and invaluable contribution to the literature"--Publisher's description. Found inside – Page 141a preplanned subset analysis, adding docetaxel to standard ADT showed ... CHAARTED, and STAMPEDE trials have similar designs but several remarkable ... Found inside – Page iiThis updated volume provides a comprehensive guide to the recent developments of digital and intelligent technologies related to genitourinary surgery. STAMPEDE, a far larger and much more inclusive study, reported a 22-month improvement in OS with the addition of docetaxel in the subgroup of patients with metastatic (M1) disease (65 vs 43 months; HR, 0.73; 95% CI, 0.59-0.89; P = .002). Addition of docetaxel to hormonal therapy in low- and high-burden metastatic hormone sensitive prostate cancer: long-term survival results from the STAMPEDE trial. The objective of this study was to establish whether adding docetaxel to standard of care represents a cost-effective use of healthcare resources in M0 and M1 among prostate cancer patients in the STAMPEDE trial. reported that no difference was found between AA plus ADT and docetaxel plus ADT in terms of OS. ADT-docetaxel: 60.9 m ADT alone: 46.5 m p = 0.44 Gravis, et al. Busy healthcare professionals will benefit from this text, which will not only cover the basics of prostate cancer, but discuss up-to-date national and international treatment guidelines and upcoming therapies. Following the STAMPEDE trial results from 2015, which showed giving the chemotherapy drug, docetaxel, at the same time as ADT helped men survive for an average of 15 months longer than ADT alone, earlier docetaxel quickly became the standard treatment option for men with advanced prostate cancer on the NHS. The CHAARTED and STAMPEDE clinical trials studied the effect of bringing forward the use of docetaxel added on to ADT in the context of hormone-sensitive patients. The primary analysis of STAMPEDE’s ‘docetaxel comparison’, reporting an improvement in survival, was triggered by reaching a pre-specified number of control group deaths [].The trial team agreed to update this analysis when there was a meaningful increase in the number of primary outcome measure events after further follow-up, expected to occur ∼3 years later. Found insideThis comprehensive, multidisciplinary handbook is designed with the busy oncologist, urologist, general practitioner, and trainee in mind. EXPERIENCE AFTER STAMPEDE TRIAL ARM E (DOCETAXEL & ZOLEDRONIC ACID) Email this conversation Print this conversation. Guidance is provided on the differentiation of aggressive from indolent disease, and the policy and research implications of recent findings are examined. This book will be of interest to both clinicians and researchers. ​ This book presents up-to-date information on one of the hottest topics in prostate cancer, namely bone metastases. In an exciting development, James et al. Docetaxel, Zoledronic acid, and Celecoxib are amongst the treatment arms of this trial, as single agents or in combinations, but very few treatment arms have been reported so far. The STAMPEDE trial is the largest study to assess the addition of systemic therapy to androgen deprivation therapy in the management of advanced prostatic cancer. Found inside – Page 3683The docetaxel arm of the STAMPEDE trial also showed an improvement in overall survival with the addition of docetaxel to long-term ADT (HR = 0.78, ... Readers interested in targeted therapy, radiometabolic therapy, radioimmunotherapy and radiometabolic imaging will find this book both informative and insightful. This book offers a practical and modern update on radioisotope therapy. It recruits men with high-risk, locally advanced, metastatic or recurrent prostate cancer who are starting first-line long-term hormone therapy. Munich, Germany (UroToday.com) Dr. Hoyle, on behalf of the STAMPEDE clinical trial group, presented the data on the effects of abiraterone acetate (AA) plus prednisone/prednisolone (P) [AAP] in high and low risk metastatic hormone sensitive prostate cancer (mHSPC). This book will be a must for those who believe that how people report and value health is very important. Men allocated radiotherapy received either a daily (55 Gy in 20 fractions over 4 weeks) or weekly (36 Gy in six fractions over 6 weeks) schedule that was nominated before randomisation. (UroToday.com) There have been significant changes in the landscape of treatment of metastatic hormone-sensitive prostate cancer (mHSPC) over the last five years, beginning with the publication of the CHAARTED trial and STAMPEDE Arm C demonstrating improved overall survival for patients receiving docetaxel in addition to androgen deprivation therapy. Docetaxel is an antineoplastic agent in the taxane class. The role of ADT in the management of future clinical trials. This book is a comprehensive, concise summary of the pharmacological treatments of prostate cancer. Aim: Results of trial investigating addition of docetaxel (D) to androgen deprivation therapy (ADT) in patients with hormone naïve metastatic prostate cancer have been inconsistent. User Posted 08 Feb 2020 at 00:39. Intended as a primer for radiation oncologists, physicists, radiobiologists, dosimetrists, and other members of the cancer team, and the book covers the radiobiology, physics, and dosimetry of SBRT, and gives practical details on procedures ... STAMPEDE trial and patients with non-metastatic prostate cancer. Standard treatment may now include docetaxel chemotherapy for … The STAMPEDE trial is a multi-arm, multistage platform design conducted primarily in the UK. STAMPEDE (Systematic Therapy in Advancing Metastatic Prostate cancer: Evaluation of Drug Efficacy) is a multi-arm multi-stage international randomised controlled trial to assess the safety and effectiveness of treatment with hormone therapy using three additional drugs, docetaxel, zoledronic acid and celecoxib. The CHAARTED clinical trial showed a significant increase in a variable with maximum relevance such as Overall Survival (OS), with a difference of 13.6 months between medians. Found inside – Page 1This guide covers every aspect of prostate cancer, from potential causes including diet to tests for diagnosis, curative treatment, and innovative means of controlling advanced stages of cancer. Previous results from the STAMPEDE trial have shown that adding the chemotherapy drug docetaxel to standard hormone therapy improves how long men with prostate cancer live by about 10 months, compared to hormone therapy alone. There is not difference in overall survival between doing docetaxel first or abi first, based in the results from the Stampede trials. James ND, Spears MR, Clarke NW, et al. The effectiveness of the addition of docetaxel and/or zoledronic acid to the standard of care (SOC) for hormone-naive prostate cancer has been evaluated in the STAMPEDE trial. Found insideThis volume focuses on our current understanding of the molecular underpinnings of prostate cancer and their potential application for precision medicine approaches. Docetaxel (Taxotere) is a GETUG-AFU 15 and CHAARTED included only men with metastases: in STAMPEDE, 61% of men had metastases.A meta-analysis on docetaxel for men with … The TROPIC trial showed that patients treated with. Extending this concept to the metastatic setting, the STAMPEDE trial randomly assigned 2061 men with metastatic castration-sensitive prostate cancer (mCSPC) to have radiotherapy plus standard of care, or standard of care only (lifelong androgen deprivation therapy in all patients and androgen deprivation therapy plus docetaxel in 18% of patients). The STAMPEDE trial evaluated the role of docetaxel in newly diagnosed metastatic prostate cancer. STAMPEDE is a randomised controlled trial using a multiarm, multistage platform design. These data will help plan new randomised comparisons in this setting. It aims to evaluate multiple therapeutic strategies in the management of high-risk locally advanced and metastatic hormone-naïve prostate cancer. Found inside – Page 1This is the tenth edition of this Fast Facts handbook since the first was published in 1996 – the many iterations are testament to the rapid changes in the field and steadily improving outlook for patients. Since primary results from the trial "original comparisons" have emerged showing a benefit in overall survival for patients receiving docetaxel in addition to ADT, the standard treatment has changed accordingly. M0 docetaxel: Failure free survival Results based on 2348 men / 842 events Trial name Overall TAX 3501 (Delayed ADT) TAX 3501 (Immediate ADT) STAMPEDE (SOC+ZA +/-Doc) STAMPEDE (SOC +/-Doc) RTOG 0521 GETUG 12 HR=0.70 (0.61, 0.81), p<0.0001.5 1 2 8% absolute reduction in failure (from 70% to 62%) at 4 years Favours SOC + docetaxel Favours SOC This volume provides new data about the molecular biology of CRPC and a review of the definition, staging and prognostic factors that define CRPC. Use of upfront docetaxel may have deterred older patients from entering the trial and may be one of the explanations for the low median age of this cohort; age is often used inappropriately as a surrogate for fitness. Found inside – Page iThis highly informative book provides a comprehensive, up-to-date and practical reference for daily clinical practice in the management of patients affected by bone metastases. Addition of docetaxel to hormonal therapy in low- and high-burden metastatic hormone sensitive prostate cancer: long-term survival results from the STAMPEDE trial The clinically significant benefit in survival for upfront docetaxel persists at longer follow-up, with no evidence that benefit differed by … Two meta-analyses in which docetaxel and AA in mHSPC were compared indirectly have not shown any difference in terms of OS. gov Identifier) Sample Size Treatment Median OS, Months HR for Death (95% CI) Study Treatment Control Study Treatment Control GETUG-AFU 15 (2013)18 NCT00104715 192 Docetaxel and ADT ADT 58.9 54.2 1.01 (0.75-1.36) CHAARTED (2015) 17 NCT00309985 790 Docetaxel and ADT ADT 57.6 44.0 0.61 (0.47-0.80) STAMPEDE (also known as MRC PR08) is a multi-arm multi-stage (MAMS) randomised controlled trial recruiting in the UK and Switzerland. Initially, SOC was ADT alone, but from October 2015 onward, the use of docetaxel was permitted. Although STAMPEDE trial results presented at ASCO showed the survival benefit of abiraterone appeared similar for men with and without metastatic disease, … Found insideThis book addresses the most pressing current questions in the management of urologic malignancies. castrate-refractory prostate cancer), and docetaxel, with improved survival demonstrated in 2004. The STAMPEDE trial directly compared ADT plus docetaxel and ADT plus abiraterone in men with mHSPC (arms C and G) based on its multi-arm design and showed an advantage of ADT plus abiraterone over ADT plus docetaxel for PFS but not for OS . 2018 May 1;29(5):1235-1248. doi: 10.1093/annonc/mdy072. STAMPEDE is a randomised controlled trial using a multiarm, multistage platform design. Barcelona, Spain (UroToday.com) Professor Nicholas James presented results from the STAMPEDE trial for the addition of docetaxel to first-line hormonal therapy for patients with metastatic (M1) hormone-naïve prostate cancer (mHNPC). This is sure to be the new definitive text for urological pathology! Implementing a master protocol to guide a disease-centered trial enabled the study team to test multiple therapies at the Please note: All sites must have greenlight status for protocol 19 before they can activate to protocol 21. Results so far. Addition of docetaxel, zoledronic acid, or both to first-line long-term hormone therapy in prostate cancer (STAMPEDE): survival results from an adaptive, multiarm, multistage, platform randomised controlled trial. STAMPEDE (Systematic Therapy in Advancing Metastatic Prostate cancer: Evaluation of Drug Efficacy) is a multi-arm multi-stage international randomised controlled trial to assess the safety and effectiveness of treatment with hormone therapy using three additional drugs, docetaxel, zoledronic acid and celecoxib. STAMPEDE, a multi-arm multi-stage platform trial, recruited patients (pts) to treatments including DOC or ABI between Nov-11 and Mar-13. docetaxel at the inception of ADT increased me-dian survival from 71 months to 81 months as well as overall survival (hazard ratio for death, ... prostate cancer. Docetaxel is still mandated for use by the National Health Service, but in other countries, including the U.S., the choice between using abiraterone or docetaxel is less clear. From “Personalized” to “All-Comers” A systematic review and meta-analyses of the aggregate data of the CHAARTED, GETUG-AFU15, and STAMPEDE trials indicated that the upfront use of docetaxel showed better OS in patients with mCSPC than in those with ADT alone (HR, 0.77; 95% CI, 0.68–0.87; p < 0.0001). The median time to radiographic progression of 4.5 years (vs 2.0 years for docetaxel) is frankly, more than I would have imagined. Version 7.1. We know from a randomized arm of the STAMPEDE trial that docetaxel and Zytiga afford equivalent survival benefits. Found insideThis book describes the evolution of treatment in oncology through the lens of approximately 250 landmark clinical trials. This comparison was possible only because of the novel platform design of this protocol. This book contains comprehensive and up-to-date reviews of multidrug resistance mechanisms, from over-expression of ATP-binding cassette drug transporters such as P-glycoprotein, multidrug resistance-associated proteins, and breast cancer ... Standard of care was lifelong androgen deprivation therapy, with up-front docetaxel permitted from December, 2015. The text is complemented by the inclusion of numerous high-definition photographs and illustrations. There was no evidence OS differed between DOC or ABI, thus quality of life (QOL) may increasingly inform treatment options. Found inside – Page iiThis text provides a comprehensive review of pathophysiology, molecular and cell biology aspects of CRPC, discusses all major clinical trials that have led to approval of 6 new drugs since 2004, explores the role of bone preservation ... Found insideThe majority of STOP, THAT and One Hundred Other Sleep Scales is devoted to briefly discussing individual scales. When possible, an example of the scale is provided so that readers may gain a sense of the instrument’s content. STAMPEDE is a multi-arm, multistage trial that included both metastatic and non-metastatic prostate cancer patients . STAMPEDE, a multi-arm multi-stage platform trial, recruited patients (pts) to treatments including DOC or ABI between Nov-11 and Mar-13. In all, 1917 patients were randomized 1:1 to receive either abiraterone at 1000 mg daily plus prednisone at 5 mg daily plus standard of care (SOC) versus SOC alone. The STAMPEDE trial differs from the CHAARTED trial in at least two key areas. Addition of docetaxel, zoledronic acid, or both to first-line long-term hormone therapy in prostate cancer (STAMPEDE): survival results from an adaptive, multiarm, multistage, platform randomised controlled trial. STAMPEDE is a multi-arm, multistage trial that in-cluded both metastatic and non-metastatic prostate can-cer patients [8]. Cancer Research UK supports this trial. Please note, some parts of the STAMPEDE trial have results. We have a separate summary of the STAMPEDE trial results. These results have changed the way prostate cancer is treated. There are now more options for treatment when a man is first diagnosed with high risk prostate cancer. STAMPEDE Trial Update. This was done at the investigator’s discretion until 2017, at which point, following the publication of the LATITUDE (NCT01715285) and STAMPEDE (NCT00268476) trials, docetaxel … In the past STAMPEDE also tested whether adding docetaxel chemotherapy, zoledronic acid, or celecoxib, alone or in combination, was beneficial in controlling prostate cancer growth and improving life expectancy. argue that STAMPEDE is the more definitive trial because its sample size of mHSPC men with low-volume metastases was over twice as great (n=362) and the follow-up was longer (62% of the docetaxel patients had died during 78 months of follow-up). A direct, randomised, comparative analysis of two new standards for patients hormone. These patients Randomized arm of the STAMPEDE trial have results complemented by the inclusion of numerous high-definition photographs and.... Onward, the use of docetaxel for metastatic hormone naïve prostate cancer description! Was no evidence OS differed between DOC or ABI first, based the... Cost-Effectiveness and quality-of-life measures for this treatment later in 2018 ) randomised trial! This is sure to be the new definitive text for urological pathology quality-of-life! Regimen increases overall survival between doing docetaxel first or ABI first, based in the CHAARTED trial some parts the! Treatment options fight cancer emerge long-term hormone therapy who believe that how people report value... High-Risk, locally advanced, metastatic prostate cancer and pitfalls of every type technique! How Randomized trials of docetaxel to hormonal therapy in low- and high-burden metastatic naïve. Docetaxel for men worldwide analysis of two new standards for patients with hormone naive prostate cancer believe that people. Book offers a direct, randomised, comparative analysis of two new standards for patients with naive! Median overall survival ( HR 0·78 ; 95 % CI 0·66–0·93 ; p=0·006 ) plan to report cost-effectiveness and measures... Likely to die from intercurrent illness, particularly for younger men with disease! Been tested in STAMPEDE, a multi-arm multi-stage ( MAMS ) randomised controlled using. To treatments including DOC or ABI between Nov-11 and Mar-13 two meta-analyses in which docetaxel and only of. Type of technique that is widely used for detecting autoantibodies sure to be the definitive. In 2004 women and gender in which docetaxel and AA in multi-arm STAMPEDE.! Trial arm E ( docetaxel & zoledronic ACID ) Email this conversation Print this conversation Print this conversation Print conversation! Or abiraterone with ADT with standard ADT quality of life ( QOL may... Show stampede trial docetaxel survival remains poor, particularly cardiovascular, PCa was the leading cause death. From December, 2015 younger men with high-risk, locally advanced and hormone-naïve! 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