Despite enormous advances made in the development of external effector prosthetics over the last quarter century, significant questions remain, especially those concerning signal degradation that occurs with chronically implanted ... The loss of skeletal muscle mass and strength substantially impairs physical performance and quality of life. This book details some approaches to the treatment of muscle wasting. This is the first book to assemble the leading researchers in the field of LRRK2 biology and neurology and provide a snapshot of the current state of knowledge, encompassing all major aspects of its function and dysfunction. The Cerebral Cortex in Neurodegenerative and Neuropsychiatric Disorders: Experimental Approaches to Clinical Issues focuses on how pre-clinical investigations are addressing the clinical issues surrounding the involvement of the cerebral ... Stem cell therapies hold considerable promise for the treatment of neurodegenerative diseases. This topic also involves the therapeutic targeting of microglial polarization by nutritional and pharmacological modulators. Moreover, this topic describes advanced technologies employed for studying microglia. Found insideWith clear, detailed color illustrations, fundamental information on a range of pharmaceutical science areas, and information on new developments in industry, pharmaceutical industry scientists, especially those involved in drug discovery ... A first-time collection of cutting-edge morphologic, permeability, transport, in vitro, and molecular techniques to study the workings of the blood-brain barrier in health and disease. Found inside – Page 35This is unlikely to happen in practice since in vitro models have proved that prions spread along the neuronal pathways (44), where infection may reach ... Disease-Modifying Targets in Neurodegenerative Disorders: Paving the Way for Disease-Modifying Therapies examines specific neurodegenerative disorders in comprehensive chapters written by experts in the respective fields. In 1993, the genetic mutation responsible for Huntington's disease (HD) was identified. Introductory chapters explain the neural and pharmacotherapeutic principles underlying these disorders, as well as the theoretical and methodological parameters needed to optimally interpret the neuroanatomical, imaging, pharmacodynamic, ... Authoritative and practical, Microglia: Methods and Protocols is a useful resource for cell biologists, molecular biologists, immunologists, oncologist and neuroscientists. Proteinopathy is a collective term used to classified neurodegenerative diseases associated with the progressive accumulation of toxic protein molecules in specific brain regions. Prospective medicinal compounds progress through multiple testing phases before becoming licensed drugs. The book proposes that a preparation of antioxidants and micronutrients, in combination with standard therapy, may reduce progression and improve management better than standard therapy alone for Alzheimer’s, Parkinson’s, and ... Worldwide there are an estimated 1 billion people that are affected by a form of neurodegenerative disease. A co-culture, or cell culture containing two separate populations of cell types, enables the study of cell-cell interactions or complex multicellular systems. Found insideThese models or rather approaches seem to be fast, cost-effective, and easy to maintain compared to primates. This book is a collection of expert essays on animal models of human diseases of global interest. This valuable new title addresses the role of heat shock proteins and cellular stress responses in the brain, with a major focus on nerve cells and glia, namely oligodendrocytes and astrocytes. Found insideThe vast amount knowledge available makes obtaining concise yet sufficient information difficult, hence the purpose of this book. In this book, embryonic stem cells, induced pluripotent stem cells, and mesenchymal stem cells are discussed. This book reviews the recent advances regarding the functions of the autophagy pathway and autophagy proteins in immunity and inflammation, focusing on their role in self-nonself distinction, their implications in innate and adaptive immune ... This book reviews the state-of-the-art in stem-cell-based therapies for neurodegenerative diseases, and highlights advances in both animal models and clinical trials. The Handbook of Developmental Neurotoxicology provides a comprehensive account of the impacts, mechanisms, and clinical relevances of chemicals on the development of the nervous system. Amyotrophic lateral sclerosis (ALS), which was described since 1869 by Jean Martin Charcot, is a devastating neurodegenerative disease characterized by the selective and progressive loss of upper and lower motor neurons of the cerebral ... This book explores the potential of stem cells for ameliorating the quality of life of patients with neurological and neurodegenerative diseases. Found insideThe dementia challenge is the largest health effort of the times we live in. This book covers state-of-the-art knowledge on the potential of stem cells for the regeneration of a wide range of tissues and organs and the technologies for studying and engineering stem cells. Neurodegenerative diseases are being modelled in-vitro using human patient-specific, induced pluripotent stem cells and transgenic embryonic stem cells to determine more about disease mechanisms, as well as to discover new treatments for ... However, there is a lack of mechanistic data to explain the numerous connections. The work presented here studied the effects of lysosomal perturbation in cultured hippocampal slices to understand why synapses are particularly vulnerable. Alzheimer's disease (AD), a neurodegenerative disease, leads to a decline in memory and other mental abilities severe enough to interfere with everyday activity. Found inside – Page 122... neuronal death in cell culture and in vivo models of neurodegenerative disorders. The third line of evidence is that caspase inhibitors or genetic ... Found inside – Page iProvides a timely overview of critical advances in molecular and cellular neurobiology, covers key methodologies driving progress, and highlights key future directions for research on neuronal injury and neurodegeneration relevant to ... The book is fully illustrated and chapters include comprehensive reference sections. Essential reading for scientists involved in prion research. Authoritative and insightful, Molecular Mechanisms of Neurodegenerative Diseases synthesizes the novel ideas and concepts now emerging to create a fresh understanding of neurodegenerative disorders, one that promises to lead to powerful new ... In this work, we develop a high-throughput platform for neuronal reprogramming to culture specific subtypes of patient-derived neurons for studying cell type-specific intrinsic properties, we establish an improved culture model of tau ... Found insideThis book aims to integrate the community of experts across the globe and the region, and to establish new challenges and developments for future investigation. We present research focused on neurodegenerative research in South America. Found insideThe book explores diagnosis, epidemiology, drug discovery strategies, current therapeutics, and much more to provide a holistic approach to the discovery, development, and treatment of Alzheimer’s Disease. The first section addresses how to locate resources, animal alternatives, animal ethics and related issues, much needed information for researchers across the biological sciences and biomedicine.The next sections of the work offers models ... This book discusses applications of pluripotent stem cells to study eye disease in vitro and to create novel therapies for degenerative eye diseases. 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